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研究成果與著作
Research and Writings

近五年論文 (Publication Lists)

  1. Chiung-Huei Peng, Chau-Jong Wang, Yen-Yu Yang, Huang CN, Huei-Jane Lee.Abelmoschus esculentus Improves Hippocampal Function Associated with Dipeptidyl Peptidase-4 in High Fat Diet-Fed db/db Mice. Journal of Food Biochemistry.First published: 16 July 2024.
  2. Yi-Sun Yang*,Edy Kornelius,Yu-Hsun Wang,Shih-Chan Lo,Huang CN,Association of dipeptidyl peptidase-4 inhibitor and recurrent pancreatitis risk among patients with type 2 diabetes: A retrospective cohort study.FRONTIERS IN PHARMACOLOGY, 04 July 2024.Sec. Drug Metabolism and Transport.Volume 15 – 2024.
  3. Sing-Hua Tsou,Sheng-Chieh Lin ,Wei-Jen Chen,Hui-Chih Hung,Chun-Cheng Liao,Edy Kornelius,Huang CN,Chih-Li Lin *,andYi-Sun Yang*.Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells.Biomedicines 2024, 12(7), 1444; Submission received: 29 May 2024 / Revised: 21 June 2024 / Accepted: 26 June 2024 / Published: 28 June 2024.
  4. Yen-Lin Chang, Oswald Ndi Nfor, Ying-Hsiang Chou, Chih-Hsuan Hsiao, Ji-Han Zhong, Huang CN & Yung-Po Liaw.Risk of diabetes mellitus based on the interactive association between G6PD rs72554664 polymorphism and sex in Taiwan Biobank individuals.Scientific reports.Published: 04 June 2024.Scientific Reports volume 14, Article number: 12802 (2024).
  5. Chih-Yao Hsu, Ching-Yuan Yeh, Tsung-Yi Yen, Ching-Chu Chen, Jung-Fu Chen , Chih-Hsun Chu, Huang CN , Ching-Ling Lin , Shih-Yi Lin,Feng-Hsuan Liu, Horng-Yih Ou, Chih-Yuan Wang.The expert consensus on care and education for patients with diabetic kidney disease in Taiwan.Primary Care Diabetes.Volume 18, Issue 3., June 2024, Pages 284-290
  6. Edy Kornelius, Shih-Chang Lo, Huang CN, Chi-Chih Wang, Yu-Hsun Wang, Yi-Sun Yang.Assessing herpes zoster vaccine efficacy in patients with diabetes: A community-based cohort study.First published: 13 May 2024.Volume96, Issue5 May 2024 e29667
  7. Feng-Chih Shen, Chih-Hsun Chu, Jung-Fu Chen, Chin-Sung Kuo, Chih-Yao Hsu, Ching-Han Lin, Yi-Jing Sheen, Sheng-Chiang Su, Kai-Jen Tien, Chieh-Hua Lu, Chun-Chuan Lee, Yi-Sun Yang, Shih-Te Tu, Po-Tsang Chen, Ching-Chu Chen, Ming-Nan Chien, Hung-Yuan Li, Wayne Huey-Herng Sheu, Huang CN, Chih-Yuan Wang, Horng-Yih Ou.Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators.Journal of Diabetes Research.27 April 2024.
  8. Yun-Kai Yeh, Kuan-Hung Lin, Wayne Huey-Herng Sheu, Su-Huey Lo, Yen-Po Yeh, Huang CN, Chii-Min Hwu & Chieh-Hsiang Lu .Determinants of early chronic kidney disease in patients with recently diagnosed type 2 diabetes mellitus: a retrospective study from the Taiwan Diabetes Registry.BMC Nephrology volume 25, Article number: 133 (2024) Published: 15 April 2024
  9. Li-An Huang, Shih-Chang Lo, Yi-Sun Yang, Huang CN, Chi-Chih Wang, Yu-Hsun Wang, and Edy Kornelius.Association of COVID-19 Infection with Subsequent Thyroid Dysfunction: An International Population-Based Propensity Score Matched Analysis.Thyroid. Vol. 34, No. 4.
  10. Ming-Lung Yu, Chih-Yuan Wang, Mei-Hsuan Lee, Horng-Yih Ou, Pin-Nan Cheng, Shih-Te Tu, Jee-Fu Huang, Jung-Fu Chen, Tsung-Hui Hu, Chih-Cheng Hsu, Jia-Horng Kao, Chien-Jen Chen, Han-Chieh Lin 及Huang CN.TASL, TADE, and DAROC consensus for the screening and management of hepatitis C in patients with diabetes.Journal of the Formosan Medical Association, 2023-03-01, 卷 122, 期 3, 頁面 202-220.
  11. Huang CN, Lin CL, Li HH, Tsou SH, Peng CH. Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function. J Med Food. 2023 Jul;26(7):462-469.
  12. Lin SC, Tsou SH, Kuo CY, Chen WL, Wu KW, Lin CL, Huang CN*. Denosumab Attenuates Glucolipotoxicity-Induced β-Cell Dysfunction and Apoptosis by Attenuating RANK/RANKL Signals. Int J Mol Sci. 2023 Jun 17;24(12):10289. 本人為通訊作者
  13. Ho LJ, Sheu WHH, Lo SH, Yeh YP, Hwu CM, Huang CN, CH Hsieh, FC Kuo. Unhealthy lifestyle associated with increased risk of macro- and micro-vascular comorbidities in patients with long-duration type 2 diabetes: results from the Taiwan Diabetes Registry. Diabetol Metab Syndr. 2023 Mar 8;15(1):38.
  14. Lo SC, E Korneliu, Liao PL, Huang JY, Yang YS, Huang CN*. Pioglitazone, SGLT2 inhibitors and their combination for primary prevention of cardiovascular disease and heart failure in type 2 diabetes: Real-world evidence from a nationwide cohort database. Diabetes Res Clin Pract. 2023 Jun;200:110685.
  15. Yang YS, Kornelius E, Lo SC, Wang YH, Huang CN. Aspirin and Risk of Specific Breast Cancer Subtype in Women with Diabetes. J Womens Health (Larchmt). 2023 Mar;32(3):341-346. Epub 2023 Jan 3.
  16. Tzung-Fang Chuang, Ying-Hsiang Chou, Jar-Yuan Pai,Huang CN, Henry Bair, Allen Pai, Nai-Chi Yu.Using Virtual Reality Technology in Biology Education: Satisfaction & Learning Outcomes of High School Students.The American Biology Teacher. (2023) 85 (1): 23–32.Volume 85, Issue 1 January 2023.
  17. Wang CY, Huang KC, Lu CW, Chu CH, Huang CN, Chen HS, Lee IT, Chen JF, Chen CC, Chen CS, Hsieh CH, Tien KJ, Chien HY, Huang YY, Hsu JP, Shane GT, Chang AC, Wu YC and Sheu WH. (2022). A Randomized Controlled Trial of R-Form Verapamil Added to Ongoing Metformin Therapy in Patients with Type 2 Diabetes. The Journal of clinical endocrinology and metabolism, 107(10), e4063–e4071
  18. Wang JS, Chin MC, Chen JF, Huang CN, Hwu CM, Ou HY, Yang YS, Hsu CC, Wang CY. Trends in hospitalizations and emergency department visits among women with hyperglycemia in pregnancy between 2008 and 2017 in Taiwan. Front Endocrinol (Lausanne). 2022 Nov 24;13:1005722.
  19. Li JC, Cheng PC, Huang CN, Jian LF, Wu YS, Lin CL.Antihypertensive treatment improves glycemic control in patients with newly diagnosed type 2 diabetes mellitus: A prospective cohort study. Front Endocrinol (Lausanne). 2022 Sep 9;13:935561.
  20. Kornelius E, Tsou SH, Chang CC, Ho YJ, Lin SC, Chen WL, Huang CN* and Lin CL. (2022, Sep).Liraglutide Attenuates Glucolipotoxicity-Induced RSC96 Schwann Cells' Inflammation and Dysfunction. Biomolecules, 12(10), 1338.
  21. Chih-Yuan Wang, Kuo-Chin Huang, Chia-Wen Lu , Chih-Hsun Chu, Chien-Ning Huang, Harn-Shen Chen, I-Te Lee, Jung-Fu Chen, Ching-Chu Chen, Chung-Sen Chen, Chang-Hsun Hsieh, Kai-Jen Tien , Hung-Yu Chien , Yu-Yao Huang , Jui-Pao Hsu , Guang-Tzuu Shane , Ai-Ching Chang , Yen-Chieh Wu, Wayne Huey-Herng Sheu . A randomized controlled trial of R-form verapamil added to ongoing metformin therapy in patients with type 2 diabetes.J Clin Endocrinol Metab. 2022 Aug 2;dgac436. Published: 02 August 2022.Online ahead of print.
  22. Cheng-Huang Su, Jiann-Shing Jeng , Shih-Te Tu, Chien-Ning Huang , Hung-I Yeh. An Effective Strategy to Activate Physicians to Promote High Cardiovascular Risk Patients to Quit Smoking.Acta Cardiol Sin. 2022 Jul;38(4):521-525.
  23. Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. Epub 2022 Jun 4. PMID: 35658024. [Corporate Author].本人為團體作者
  24. Chia-Hung Lin , Yi-Ching Tung, Tien-Jyun Chang, Chien-Ning Huang, Chii-Min Hwu, for Taiwan Type 1 DM Consortium. Use of expert consensus to improve the diagnosis and management of type 1 diabetes mellitus. J Chin Med Assoc. 2022 Jul 1;85(7):741-746. Epub 2022 Jun 30.
  25.  Chih-Chun Chuang, Yi-Sun Yang, Edy Kornelius, Chien-Ning Huang, Min-Yen Hsu, Chia-Yi Lee , Shun-Fa Yang. Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy.Front Genet.2022 Apr25;13:889530. 2022.
  26. Ying-Hsiang Chou, Yung-Yin Cheng, Oswald Ndi Nfor , Pei-Hsin Chen, Che-Hong Chen, Hsin-Lin Chen, Bo-Jiun Chang, Disline Manli Tantoh, Chien-Ning Huang*, Yung-Po Liaw.Effects of aerobic and resistance exercise on glycosylated hemoglobin (HbA1c) concentrations in non-diabetic Taiwanese individuals based on the waist-hip ratio.PLoS One. 2022 May 5;17(5):e0267387. eCollection 2022.
  27. Chee-Ming Lee, Yi-Sun Yang, Edy Korneliu, Chien-Ning Huang, Min-Yen Hsu, Chia-Yi Lee, Shu-Yen Peng, Shun-Fa Yang.Association of Long Non-Coding RNA Growth Arrest-Specific 5 Genetic Variants with Diabetic Retinopathy.Genes (Basel). 2022 Mar 25;13(4):584.
  28. Chiung-Huei Peng, Yaw-Bee Ker, Hsin-Hua Li, Sing-Hua Tsou, Chih-Li Lin, Chien-Ning Huang*.Abelmoschus esculentus subfractions ameliorate hepatic lipogenesis and lipid uptake via regulating dipeptidyl peptidase-4-With improving insulin resistance.PLoS One. 2022 Mar 15;17(3):e0265444. eCollection 2022.
  29. Yi-Sun Yang, Hsin-Hung Chen, Chien-Ning Huang, Chung Y Hsu, Kai-Chieh Hu, Chia-Hung Kao.GLP-1RAs for Ischemic Stroke Prevention in Patients With Type 2 Diabetes Without Established Atherosclerotic Cardiovascular Disease.Diabetes Care. 2022 May 1;45(5):1184-1192.
  30. Chao-Chung Ho, Yi-Sun Yang, Chien-Ning Huang, Shih-Chang Lo, Yu-Hsun Wang, Edy Kornelius.The efficacy of pioglitazone for renal protection in diabetic kidney disease.PLoS One. 2022 Feb 17;17(2):e0264129. eCollection 2022.
  31. Yi-Sun Yang, Nian-Yi Wu, Edy Kornelius, Chien-Ning Huang, Nae-Cherng Yang.A randomized, double-blind, placebo-controlled trial to evaluate the hypoglycemic efficacy of the mcIRBP-19-containing Momordica charantia L. fruit extracts in the type 2 diabetic subjects.Food Nutr Res. 2022 Jan 3;66. doi: 10.29219/fnr.v66.3685. eCollection 2022.
  32. Min-Yen Hsu, Jeng-Yuan Chiou , Jung-Tzu Liu , Chee-Ming Lee, Ya-Wen Lee , Chien-Chih Chou , Shih-Chang Lo, Edy Kornelius, Yi-Sun Yang, Sung-Yen Chang , Yu-Cheng Liu, Huang CN, Vincent S Tseng .Deep Learning for Automated Diabetic Retinopathy Screening Fused With Heterogeneous Data From EHRs Can Lead to Earlier Referral Decisions. Transl Vis Sci Technol. 2021 Aug 2;10(9):18.
  33. Jun-Sing Wang, Su-Huey Lo, Yen-Po Yeh, Chii-Min Hwu, Huang CN, Chang-Hsun Hsieh, Wayne Huey-Herng Sheu. Distinct associations of self-monitoring of blood glucose with glycemic control and hypoglycemia between groups of recently diagnosed and long-term follow-up type 2 diabetes: the Taiwan Diabetes Registry. Int J Clin Pract. 2021 May 28;e14410.
  34. Chia-Hsun Chang, Ching-Pyng Kuo, Huang CN, Shiow-Li Hwang, Wen-Chun Liao, Meng-Chih Lee. Habitual Physical Activity and Diabetes Control in Young and Older Adults with Type II Diabetes: A Longitudinal Correlational Study. Int J Environ Res Public Health. 2021 Feb 2;18(3):1330.
  35. Ching-Pyng Kuo, Shu-Hua Lu, Huang CN, Wen-Chun Liao, Meng-Chih Lee. Sleep Quality and Associated Factors in Adults with Type 2 Diabetes: A Retrospective Cohort Study. Int J Environ Res Public Health. 2021 Mar 15;18(6):3025.
  36. Kornelius E, Huang CN, Lo SC, Wang YH, Yang YS (2020, Dec). Dipeptidyl-Peptidase 4 Inhibitors did not Improve Renal Endpoints in Advanced Diabetic Kidney Disease. Endocrine Practice, 26(12), 1486-1496
  37. Huang CN, Chau-Jong Wang, Chih-Li Lin, Hsin-Hua Li, An-Ting Yen, Chiung-Huei Peng. Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals. BMC Complement Med Ther. 2020 Dec 2;20(1):370.
  38. Linong Ji , Juliana C N Chan , Miao Yu , Kun Ho Yoon, Sin Gon Kim , Sung Hee Choi  , Huang CN, Shih Te Tu, Chih-Yuan Wang 10, Päivi Maria Paldánius, Wayne H H Sheu. Early combination versus initial metformin monotherapy in the management of newly diagnosed type 2 diabetes: An East Asian perspective. Diabetes Obes Metab 2021 Jan;23(1):3-17. Epub 2020 Nov 9.
  39. Ying-Hsiang Chou, Disline Manli Tantoh , Ming-Chi Wu, Yeu-Sheng Tyan,Pei-Hsin Chen, Oswald Ndi Nfor , Shu-Yi Hsu, Chao-Yu Shen, Huang CN*, Yung-Po Liaw. PM 2.5 exposure and DLEC1 promoter methylation in Taiwan Biobank participants. Environ Health Prev Med. 2020 Nov 5;25(1):68.
  40. Li-You Chen, Huang CN, Chih-Kai Liao, Hung-Ming Chang , Yu-Hsiang Kuan , To-Jung Tseng , Kai-Jung Yen, Kai-Lin Yang, Hsing-Chun Lin. Effects of Rutin on Wound Healing in Hyperglycemic Rats. Antioxidants (Basel). 2020 Nov 13;9(11):1122.
  41.  Ming-Cheng Wei, Edy Kornelius, Ying-Hsiang Chou, Yi-Sun Yang, Jing-Yang Huang, Huang CN*. Optimal Initial Blood Pressure in Intensive Care Unit Patients with Non-Traumatic Intracranial Hemorrhage. Int J Environ Res Public Health. 2020 May 14;17(10):3436.
  42. Edy Kornelius, Shih-Chang Lo,  Huang CN, Yi-Sun Yang.THE RISK OF THYROID CANCER IN PATIENTS WITH THYROID NODULE 3 CM OR LARGER. Endocr Pract. 2020 Jul 13. Online ahead of print.
  43. Ming-Cheng Wei,Ying-Hsiang Chou,Yi-Sun Yang, Edy Kornelius, Yu-Hsun Wang, Huang CN*.Osteoporosis and Stress Urinary Incontinence in Women: A National Health Insurance Database Study. Int J Environ Res Public Health. 2020 Jun 21;17(12):4449.
  44. Yerin Hwang,Altaisaikhan Khasag, Weiping Jia ,Alicia Jenkins, Huang CN, Daisuke Yabe , Doo-Man Kim, Takashi Kadowaki , Moon-Kyu Lee. Diabetes and COVID-19: IDF perspective in the Western Pacific region. Diabetes Res Clin Pract. 2020 Aug;166:108278. Epub 2020 Jun 25.
  45. Kornelius E, Lo SC, Huang CN, Wang YH, Yang YS. Association of blood glucose and renal end points in advanced diabetic kidney disease.  Diabetes Research and Clinical Practice. 2020 Mar;161:108011. Epub 2020 Jan 25
  46. Chiung-Huei Peng, Jia-Jen Cheng, Meng-Hsun Yu, Dai-Jung Chung,  Huang CN*, Chau-Jong Wang. Solanum nigrum polyphenols reduce body weight and body fat by affecting adipocyte and lipid metabolism. Food Funct. 2020 Jan 29;11(1):483-492.
  47. Chou YH, Huang JY, Kornelius E, Chiou JY, Huang CN* . Major Adverse Cardiovascular Events after Treatment in Early-stage Breast Cancer Patients Receiving Hormone Therapy.  Scientific Reports 2020 Jan 29;10(1):1408.
  48. Sheen YJ, Hsu CC, Jiang YD, Huang CN, Liu JS, Sheu WH. Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan. Journal of the Formosan Medical Association. 2019 Nov;118 Suppl 2:S66-S73. Epub 2019 Jul 9.
  49. Yang TW, Lee WH, Tu SJ, Huang WC, Chen HM, Sun TH, Tsai MC, Wang CC, Chen HY, Huang CC, Shiu BH, Yang TL, Huang HT, Chou YP, Chou CH, Huang YR, Sun YR, Liang C, Lin FM, Ho SY, Chen WL, Yang SF, Ueng KC, Huang HD, Huang CN, Jong YJ, Lin CC. Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway. Scientific Reports 2019 Jul 29;9(1):10923.
  50. Lo SC, Yang YS, Kornelius E, Huang JY, Lai YR, Huang CN, Chiou JY. Early cardiovascular risk and all-cause mortality following an incident of severe hypoglycaemia: A population-based cohort study. Diabetes Obes Metab. 2019 Aug; 21(8):1878-1885. Epub 2019 May 9.
  51. Wu YC, Kornelius E, Yang YS, Chen YF, Huang CN. An Educational Intervention Using Steno Balance Cards to Improve Glycemic Control in Patients With Poorly Controlled Type 2 Diabetes Mellitus. Journal of Nursing Research 2019 Feb;27(1):1-7.
  52. Lin HC, Peng CH, Huang CN, Chiou JY. Soy-Based Foods Are Negatively Associated with Cognitive Decline in Taiwan's Elderly. J Nutr Sci Vitaminol (Tokyo). 64(5):335-339; October 2018.
  53. Kornelius E, Li HH, Peng CH, Yang YS, Chen WJ, Chang YZ, Bai YC, Liu S, Huang CN, Lin CL. Liraglutide protects against glucolipotoxicity-induced RIN-m5F β-cell apoptosis through restoration of PDX1 expression. Journal of cellular and molecular medicine. August 2018.
  54. Mohan V, Ahn KJ, Cho YM, Sahay RK, Huang CN, Kalra S, Chadha M, Bhattacharya I, Kim SY, Spaepen E. Lilly Insulin Glargine Versus Lantus® in Type 2 Diabetes Mellitus Patients: India and East Asia Subpopulation Analyses of the ELEMENT 5 Study. Clinical Drug Investigation. 2019 May 22.